Using Drosophila as a model, the Tower lab is undertaking a multi-pronged and genome-wide analysis of aging and DNA replication. We are currently studying the regulation of hsp gene expression during aging, the role of superoxide dismutase in regulating life span, genome-wide analysis of gene expression in response to aging and stress, and the regulation of life span and somatic stem cell aging by p53. We have developed novel P element mutagenesis techniques to identify genes that regulate Drosophila life span, and have developed video-tracking methods that have revealed predictive biomarkers of life span.
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